Use of Lip Protecting Agents in the Prevention of Actinic Cheilitis, Herpes Labialis and Cancer of Lip: A Systematic Review

Background: Actinic cheilitis, herpes labialis and lip cancer are relatively common conditions presenting on the lips associated with exposure to periods of sun thereby ultraviolet radiation. Objective: This systematic review aimed determine efficacy application sunscreen-containing lip-protecting agents (LPA) in prevention actinic cheilitis (AC), recurrent (RHL) (LC). Methods: was conducted accordance PRISMA guidelines registered PROSPERO database. A literature search using SCOPUS, Google Scholar, Medline (Ovid), Pubmed, CINAHL, Cochrane Library databases manual terms (LC) along protecting their variations as keywords. total 1,567 papers were yielded. Of them, nine studies eligible for qualitative data synthesis. Results: Nine articles (3 AC, 5 RHL, 1 LC) deemed thus selected Three AC identified approximately 21.7% lower prevalence lesions when some form protection used. Eighty percent RHL that LPA is effective preventing RHL. Subjects who applied more than once daily only had half risk having LC compared those daily. Conclusion: randomised controlled trials (RCTs) observational supports use an method lip-associated lesions. Further, RCTs should aim at determining a definitive regime optimal SPF strength prevent International Prospective Register Systematic Reviews (PROSPERO): Registration Number - CRD42020177484. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020177484